Exploration of regiospecificity phenomenon in [2+3] cycloaddition reactions between arylnitrones and trans-substituted nitroethenes on the basis of the reactivity indices theory


Radomir Jasiński


Analysis of global electrophilicity and nucleophilicity power of the addends indicate polar character of [2+3] cycloaddition reactions between arylnitrones and trans-substituted nitroethenes. The regioselectivity of these reactions is determined by nucleophilic attack of oxygen atom from nitrone on activated -position of nitroalkene. Interaction of this type leads to 4-nitroisoxazolidines, which are the only reaction products.


DOI: j.ccl.2012.8.001

Keywords: [2+3] Cycloaddition ,Nitrone ,Nitroalkene ,Electrophilicity ,Regioselectivity

How to cite this paper:

Jasiński, R. (2012). Exploration of regiospecificity phenomenon in [2+3] cycloaddition reactions between arylnitrones and trans-substituted nitroethenes on the basis of the reactivity indices theory.Current Chemistry Letters, 1(4), 157-162.


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